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4igz

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{{STRUCTURE_4igz| PDB=4igz | SCENE= }}
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#REDIRECT [[5vei]] This PDB entry is obsolete and replaced by 5vei
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===Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2===
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==Function==
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[[http://www.uniprot.org/uniprot/SRBS2_HUMAN SRBS2_HUMAN]] Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.<ref>PMID:9211900</ref><ref>PMID:12475393</ref>
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==About this Structure==
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[[4igz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGZ OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bakkouri, M El.]]
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[[Category: Bountra, C.]]
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[[Category: Edwards, A M.]]
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[[Category: Gu, J.]]
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[[Category: Huang, H.]]
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[[Category: Liu, K.]]
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[[Category: Liu, Y.]]
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[[Category: Min, J.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sidhu, S S.]]
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[[Category: Tempel, W.]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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[[Category: Sh3]]
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[[Category: Src homology 3 domain]]
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[[Category: Structural genomics consortium]]
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Current revision

  1. REDIRECT 5vei This PDB entry is obsolete and replaced by 5vei

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