4ilh

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{{STRUCTURE_4ilh| PDB=4ilh | SCENE= }}
 
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===Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH===
 
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==Function==
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==Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH==
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[[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref><ref>PMID:9150140</ref><ref>PMID:12773561</ref><ref>PMID:18779563</ref> [[http://www.uniprot.org/uniprot/AAR2_YEAST AAR2_YEAST]] Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.
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<StructureSection load='4ilh' size='340' side='right'caption='[[4ilh]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ilh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilh OCA], [https://pdbe.org/4ilh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilh RCSB], [https://www.ebi.ac.uk/pdbsum/4ilh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
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==About this Structure==
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==See Also==
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[[4ilh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILH OCA].
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Saccharomyces cerevisiae s288c]]
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</StructureSection>
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[[Category: Heroven, A C.]]
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[[Category: Large Structures]]
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[[Category: Santos, K F.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Wahl, M C.]]
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[[Category: Heroven AC]]
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[[Category: Weber, G.]]
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[[Category: Santos KF]]
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[[Category: Aar2]]
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[[Category: Wahl MC]]
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[[Category: Prp8]]
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[[Category: Weber G]]
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[[Category: Splicing]]
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[[Category: U5 snrnp assembly]]
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Current revision

Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH

PDB ID 4ilh

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