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2dly
From Proteopedia
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| - | [[Image:2dly.jpg|left|200px]]<br /><applet load="2dly" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dly" /> | ||
| - | '''Solution structure of the SH2 domain of murine Fyn-related kinase'''<br /> | ||
| - | == | + | ==Solution structure of the SH2 domain of murine Fyn-related kinase== |
| - | + | <StructureSection load='2dly' size='340' side='right'caption='[[2dly]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2dly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dly OCA], [https://pdbe.org/2dly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dly RCSB], [https://www.ebi.ac.uk/pdbsum/2dly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dly ProSAT], [https://www.topsan.org/Proteins/RSGI/2dly TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FRK_MOUSE FRK_MOUSE] Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dly_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dly ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Endo H]] | |
| - | [[Category: Endo | + | [[Category: Hayashi F]] |
| - | [[Category: Hayashi | + | [[Category: Yokoyama S]] |
| - | + | [[Category: Yoshida M]] | |
| - | [[Category: Yokoyama | + | |
| - | [[Category: Yoshida | + | |
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Current revision
Solution structure of the SH2 domain of murine Fyn-related kinase
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