3jur
From Proteopedia
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| - | {{STRUCTURE_3jur| PDB=3jur | SCENE= }} | ||
| - | ===The crystal structure of a hyperthermoactive Exopolygalacturonase from Thermotoga maritima=== | ||
| - | {{ABSTRACT_PUBMED_19854184}} | ||
| - | == | + | ==The crystal structure of a hyperthermoactive Exopolygalacturonase from Thermotoga maritima== |
| - | [[3jur]] is a 4 chain structure with sequence from [ | + | <StructureSection load='3jur' size='340' side='right'caption='[[3jur]], [[Resolution|resolution]] 2.05Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3jur]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jur OCA], [https://pdbe.org/3jur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jur RCSB], [https://www.ebi.ac.uk/pdbsum/3jur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jur ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9WYR8_THEMA Q9WYR8_THEMA] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jur_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jur ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The exopolygalacturonase from Thermotoga maritima is the most thermoactive and thermostable pectinase known to date. Here we present its crystal structure at 2.05A resolution. High structural homology around the active site allowed us to propose a model for substrate binding, explaining the exo-cleavage activity and specificity for non-methylated saturated galacturonate at the non-reducing end. Furthermore, the structure reveals unique features that contribute to the formation of stable tetramers in solution. Such an oligomerization has not been observed before for polygalacturonases. | ||
| - | + | The crystal structure of a hyperthermoactive exopolygalacturonase from Thermotoga maritima reveals a unique tetramer.,Pijning T, van Pouderoyen G, Kluskens L, van der Oost J, Dijkstra BW FEBS Lett. 2009 Nov 19;583(22):3665-70. Epub 2009 Oct 23. PMID:19854184<ref>PMID:19854184</ref> | |
| - | <ref | + | |
| - | [[Category: | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| + | </div> | ||
| + | <div class="pdbe-citations 3jur" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| - | [[Category: Dijkstra | + | [[Category: Dijkstra BW]] |
| - | [[Category: Kluskens | + | [[Category: Kluskens LD]] |
| - | + | [[Category: Pijning T]] | |
| - | [[Category: Pijning | + | [[Category: Van Pouderoyen G]] |
| - | [[Category: Pouderoyen | + | [[Category: Van der Oost J]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
The crystal structure of a hyperthermoactive Exopolygalacturonase from Thermotoga maritima
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