3jve

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{{STRUCTURE_3jve| PDB=3jve | SCENE= }}
 
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===Crystal Structure of the Sixth BRCT Domain of TopBP1===
 
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{{ABSTRACT_PUBMED_19937654}}
 
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==Function==
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==Crystal Structure of the Sixth BRCT Domain of TopBP1==
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[[http://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN]] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref><ref>PMID:11395493</ref><ref>PMID:11714696</ref><ref>PMID:12697828</ref><ref>PMID:15075294</ref><ref>PMID:16530042</ref>
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<StructureSection load='3jve' size='340' side='right'caption='[[3jve]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JVE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jve OCA], [https://pdbe.org/3jve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jve RCSB], [https://www.ebi.ac.uk/pdbsum/3jve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jve ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOPB1_HUMAN TOPB1_HUMAN] Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.<ref>PMID:10498869</ref> <ref>PMID:11395493</ref> <ref>PMID:11714696</ref> <ref>PMID:12697828</ref> <ref>PMID:15075294</ref> <ref>PMID:16530042</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jv/3jve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jve ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3jve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JVE OCA].
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*[[Topoisomerase binding protein|Topoisomerase binding protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019937654</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Baker, D.]]
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[[Category: Large Structures]]
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[[Category: Glover, J N.M.]]
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[[Category: Baker D]]
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[[Category: Kellogg, E.]]
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[[Category: Glover JNM]]
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[[Category: Leung, C C.]]
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[[Category: Kellogg E]]
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[[Category: Brct domain]]
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[[Category: Leung CC]]
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[[Category: Dna binding protein]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Dna-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of the Sixth BRCT Domain of TopBP1

PDB ID 3jve

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