3jzn

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{{STRUCTURE_3jzn| PDB=3jzn | SCENE= }}
 
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===Structure of EED in apo form===
 
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{{ABSTRACT_PUBMED_20974918}}
 
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==Function==
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==Structure of EED in apo form==
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[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref><ref>PMID:10581039</ref><ref>PMID:14532106</ref><ref>PMID:15385962</ref><ref>PMID:15231737</ref><ref>PMID:15225548</ref><ref>PMID:16357870</ref><ref>PMID:18285464</ref><ref>PMID:20974918</ref>
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<StructureSection load='3jzn' size='340' side='right'caption='[[3jzn]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzn OCA], [https://pdbe.org/3jzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzn RCSB], [https://www.ebi.ac.uk/pdbsum/3jzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzn ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3jzn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZN OCA].
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020974918</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bian, C B.]]
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[[Category: Large Structures]]
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[[Category: MacKenzie, F.]]
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[[Category: Bian CB]]
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[[Category: Min, J.]]
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[[Category: MacKenzie F]]
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[[Category: Ouyang, H.]]
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[[Category: Min J]]
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[[Category: Qiu, W.]]
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[[Category: Ouyang H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Qiu W]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Alternative initiation]]
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[[Category: Chromatin regulator]]
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[[Category: Gene regulation]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Repressor]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Wd repeat]]
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[[Category: Wd40]]
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Current revision

Structure of EED in apo form

PDB ID 3jzn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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