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3jwp

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{{STRUCTURE_3jwp| PDB=3jwp | SCENE= }}
 
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===Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP===
 
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==Function==
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==Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP==
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[[http://www.uniprot.org/uniprot/Q8IE47_PLAF7 Q8IE47_PLAF7]] NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.<ref>PMID:15820676</ref><ref>PMID:17827348</ref><ref>PMID:18729382</ref><ref>PMID:18397290</ref><ref>PMID:18525026</ref><ref>PMID:18221799</ref><ref>PMID:19402747</ref><ref>PMID:20601220</ref>
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<StructureSection load='3jwp' size='340' side='right' caption='[[3jwp]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3jwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JWP FirstGlance]. <br>
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[[3jwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWP OCA].
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF13_0152, Sir2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
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<references group="xtra"/><references/>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwp OCA], [http://pdbe.org/3jwp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jwp RCSB], [http://www.ebi.ac.uk/pdbsum/3jwp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwp ProSAT]</span></td></tr>
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[[Category: Plasmodium falciparum]]
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</table>
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[[Category: Allali-Hassanali, A.]]
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== Function ==
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[[Category: Arrowsmith, C H.]]
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[[http://www.uniprot.org/uniprot/SIR5_PLAF7 SIR5_PLAF7]] NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.<ref>PMID:15820676</ref> <ref>PMID:17827348</ref> <ref>PMID:18221799</ref> <ref>PMID:18397290</ref> <ref>PMID:18525026</ref> <ref>PMID:18729382</ref> <ref>PMID:19402747</ref> <ref>PMID:20601220</ref>
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[[Category: Bountra, C.]]
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== Evolutionary Conservation ==
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[[Category: Brand, V.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Cossar, D.]]
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Check<jmol>
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[[Category: Edwards, A M.]]
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<jmolCheckbox>
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[[Category: Hui, R.]]
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwp_consurf.spt"</scriptWhenChecked>
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[[Category: Hutchinson, A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Kozieradzki, I.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Lin, Y H.]]
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</jmolCheckbox>
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[[Category: MacKenzie, F.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jwp ConSurf].
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[[Category: Qiu, W.]]
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<div style="clear:both"></div>
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[[Category: Ravichandran, M.]]
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== References ==
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[[Category: SGC, Structural Genomics Consortium.]]
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<references/>
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[[Category: Schapira, M.]]
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__TOC__
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[[Category: Senisterra, G.]]
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</StructureSection>
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[[Category: Vedadi, M.]]
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[[Category: Plaf7]]
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[[Category: Weigelt, J.]]
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[[Category: Allali-Hassanali, A]]
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[[Category: Wernimont, A K.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Zhao, Y.]]
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[[Category: Bountra, C]]
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[[Category: Brand, V]]
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[[Category: Cossar, D]]
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[[Category: Edwards, A M]]
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[[Category: Hui, R]]
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[[Category: Hutchinson, A]]
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[[Category: Kozieradzki, I]]
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[[Category: Lin, Y H]]
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[[Category: MacKenzie, F]]
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[[Category: Qiu, W]]
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[[Category: Ravichandran, M]]
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[[Category: Structural genomic]]
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[[Category: Schapira, M]]
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[[Category: Senisterra, G]]
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[[Category: Vedadi, M]]
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[[Category: Weigelt, J]]
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[[Category: Wernimont, A K]]
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[[Category: Zhao, Y]]
[[Category: Malaria]]
[[Category: Malaria]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]

Current revision

Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP

3jwp, resolution 2.65Å

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