3gf7

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{{STRUCTURE_3gf7| PDB=3gf7 | SCENE= }}
 
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===Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein===
 
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{{ABSTRACT_PUBMED_019654317}}
 
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==About this Structure==
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==Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein==
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[[3gf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_symbiosum Clostridium symbiosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF7 OCA].
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<StructureSection load='3gf7' size='340' side='right'caption='[[3gf7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_symbiosum Clostridium symbiosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf7 OCA], [https://pdbe.org/3gf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B7TVP1_CLOSY B7TVP1_CLOSY]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glutaconyl-CoA decarboxylase (Gcd) couples the biotin-dependent decarboxylation of glutaconyl-CoA with the generation of an electrochemical Na(+) gradient. Sequencing of the genes encoding all subunits of the Clostridium symbiosum decarboxylase membrane complex revealed that it comprises two distinct biotin carrier subunits, GcdC(1) and GcdC(2), which differ in the length of a central alanine- and proline-rich linker domain. Co-crystallization of the decarboxylase subunit GcdA with the substrate glutaconyl-CoA, the product crotonyl-CoA, and the substrate analogue glutaryl-CoA, respectively, resulted in a high resolution model for substrate binding and catalysis revealing remarkable structural changes upon substrate binding. Unlike the GcdA structure from Acidaminococcus fermentans, these data suggest that in intact Gcd complexes, GcdA is associated as a tetramer crisscrossed by a network of solvent-filled tunnels.
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==Reference==
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An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases.,Kress D, Brugel D, Schall I, Linder D, Buckel W, Essen LO J Biol Chem. 2009 Oct 9;284(41):28401-9. Epub 2009 Aug 4. PMID:19654317<ref>PMID:19654317</ref>
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<ref group="xtra">PMID:019654317</ref><references group="xtra"/><references/>
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[[Category: Clostridium symbiosum]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Glutaconyl-CoA decarboxylase]]
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</div>
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[[Category: Brugel, D.]]
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<div class="pdbe-citations 3gf7" style="background-color:#fffaf0;"></div>
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[[Category: Buckel, W.]]
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== References ==
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[[Category: Essen, L O.]]
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<references/>
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[[Category: Kress, D.]]
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__TOC__
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[[Category: Biotin]]
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</StructureSection>
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[[Category: Glutaconyl-coa decarboxylase]]
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[[Category: Large Structures]]
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[[Category: Glutamate fermentation]]
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[[Category: Brugel D]]
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[[Category: Lyase]]
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[[Category: Buckel W]]
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[[Category: Sodium ion transport]]
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[[Category: Essen L-O]]
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[[Category: Kress D]]

Current revision

Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein

PDB ID 3gf7

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