3iqs

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{{STRUCTURE_3iqs| PDB=3iqs | SCENE= }}
 
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===Crystal structure of the anti-viral APOBEC3G catalytic domain===
 
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{{ABSTRACT_PUBMED_18849968}}
 
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==Function==
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==Crystal structure of the anti-viral APOBEC3G catalytic domain==
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[[http://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN]] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref><ref>PMID:12167863</ref><ref>PMID:12808466</ref><ref>PMID:12809610</ref><ref>PMID:12808465</ref><ref>PMID:12859895</ref><ref>PMID:12970355</ref><ref>PMID:14528300</ref><ref>PMID:15031497</ref><ref>PMID:16527742</ref><ref>PMID:21123384</ref><ref>PMID:18288108</ref>
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<StructureSection load='3iqs' size='340' side='right'caption='[[3iqs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3iqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IQS FirstGlance]. <br>
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[[3iqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IQS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iqs OCA], [https://pdbe.org/3iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iqs RCSB], [https://www.ebi.ac.uk/pdbsum/3iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iqs ProSAT]</span></td></tr>
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<ref group="xtra">PMID:018849968</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref> <ref>PMID:12167863</ref> <ref>PMID:12808466</ref> <ref>PMID:12809610</ref> <ref>PMID:12808465</ref> <ref>PMID:12859895</ref> <ref>PMID:12970355</ref> <ref>PMID:14528300</ref> <ref>PMID:15031497</ref> <ref>PMID:16527742</ref> <ref>PMID:21123384</ref> <ref>PMID:18288108</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/3iqs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iqs ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bransteitter, R.]]
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[[Category: Large Structures]]
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[[Category: Chang, Y P.]]
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[[Category: Bransteitter R]]
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[[Category: Chelico, L.]]
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[[Category: Chang YP]]
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[[Category: Chen, X S.]]
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[[Category: Chelico L]]
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[[Category: Goodman, R F.]]
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[[Category: Chen XS]]
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[[Category: Holden, L G.]]
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[[Category: Goodman RF]]
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[[Category: Prochnow, C.]]
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[[Category: Holden LG]]
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[[Category: Sen, U.]]
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[[Category: Prochnow C]]
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[[Category: Stevens, R C.]]
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[[Category: Sen U]]
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[[Category: Antiviral defense]]
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[[Category: Stevens RC]]
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[[Category: Five beta-strands surrounded by six alpha-helice]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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Current revision

Crystal structure of the anti-viral APOBEC3G catalytic domain

PDB ID 3iqs

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