3iug

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{{STRUCTURE_3iug| PDB=3iug | SCENE= }}
 
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===Crystal structure of the RhoGAP domain of RICS===
 
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==Function==
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==Crystal structure of the RhoGAP domain of RICS==
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[[http://www.uniprot.org/uniprot/RICS_HUMAN RICS_HUMAN]] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).<ref>PMID:12446789</ref><ref>PMID:12819203</ref><ref>PMID:17663722</ref><ref>PMID:12788081</ref><ref>PMID:12454018</ref><ref>PMID:12531901</ref><ref>PMID:12857875</ref>
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<StructureSection load='3iug' size='340' side='right'caption='[[3iug]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3iug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IUG FirstGlance]. <br>
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[[3iug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IUG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iug OCA], [https://pdbe.org/3iug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iug RCSB], [https://www.ebi.ac.uk/pdbsum/3iug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iug ProSAT]</span></td></tr>
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<references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHG32_HUMAN RHG32_HUMAN] GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iug_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iug ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Bountra C]]
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[[Category: Li, Y.]]
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[[Category: Edwards AM]]
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[[Category: Nedyalkova, L.]]
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[[Category: Li Y]]
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[[Category: Park, H.]]
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[[Category: Nedyalkova L]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Tong, Y.]]
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[[Category: Tong Y]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cell projection]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Endosome]]
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[[Category: Gap]]
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[[Category: Golgi apparatus]]
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[[Category: Gtpase activation]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: Sh3 domain]]
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[[Category: Splicing]]
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[[Category: Synapse]]
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Current revision

Crystal structure of the RhoGAP domain of RICS

PDB ID 3iug

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