2ver

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{{STRUCTURE_2ver| PDB=2ver | SCENE= }}
 
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===STRUCTURAL MODEL FOR THE COMPLEX BETWEEN THE DR ADHESINS AND CARCINOEMBRYONIC ANTIGEN (CEA)===
 
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{{ABSTRACT_PUBMED_18086185}}
 
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==Function==
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==Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA)==
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[[http://www.uniprot.org/uniprot/AFAE3_ECOLX AFAE3_ECOLX]] Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)). [[http://www.uniprot.org/uniprot/CEAM5_HUMAN CEAM5_HUMAN]] Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.<ref>PMID:10864933</ref>
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<StructureSection load='2ver' size='340' side='right'caption='[[2ver]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ver]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VER FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e07|1e07]], [[1ut2|1ut2]], [[1usz|1usz]], [[2ixq|2ixq]], [[1rxl|1rxl]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ver FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ver OCA], [https://pdbe.org/2ver PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ver RCSB], [https://www.ebi.ac.uk/pdbsum/2ver PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ver ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/AFAE3_ECOLX AFAE3_ECOLX]] Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)). [[https://www.uniprot.org/uniprot/CEAM5_HUMAN CEAM5_HUMAN]] Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.<ref>PMID:10864933</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ver_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ver ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) are host receptors for the Dr family of adhesins of Escherichia coli. To define the mechanism for binding of Dr adhesins to CEACAM receptors, we carried out structural studies on the N-terminal domain of CEA and its complex with the Dr adhesin. The crystal structure of CEA reveals a dimer similar to other dimers formed by receptors with IgV-like domains. The structure of the CEA/Dr adhesin complex is proposed based on NMR spectroscopy and mutagenesis data in combination with biochemical characterization. The Dr adhesin/CEA interface overlaps appreciably with the region responsible for CEA dimerization. Binding kinetics, mutational analysis and spectroscopic examination of CEA dimers suggest that Dr adhesins can dissociate CEA dimers prior to the binding of monomeric forms. Our conclusions include a plausible mechanism for how E. coli, and perhaps other bacterial and viral pathogens, exploit CEACAMs. The present structure of the complex provides a powerful tool for the design of novel inhibitory strategies to treat E. coli infections.
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==About this Structure==
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Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation.,Korotkova N, Yang Y, Le Trong I, Cota E, Demeler B, Marchant J, Thomas WE, Stenkamp RE, Moseley SL, Matthews S Mol Microbiol. 2008 Jan;67(2):420-34. Epub 2007 Dec 11. PMID:18086185<ref>PMID:18086185</ref>
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[[2ver]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VER OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:018086185</ref><references group="xtra"/><references/>
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</div>
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[[Category: Escherichia coli]]
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<div class="pdbe-citations 2ver" style="background-color:#fffaf0;"></div>
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[[Category: Homo sapiens]]
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== References ==
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[[Category: Cota, E.]]
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<references/>
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[[Category: Demeler, B.]]
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__TOC__
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[[Category: Korotkova, N.]]
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</StructureSection>
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[[Category: Marchant, J.]]
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[[Category: Bacillus coli migula 1895]]
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[[Category: Matthews, S.]]
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[[Category: Human]]
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[[Category: Moseley, S L.]]
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[[Category: Large Structures]]
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[[Category: Stenkamp, R E.]]
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[[Category: Cota, E]]
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[[Category: Thomas, W E.]]
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[[Category: Demeler, B]]
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[[Category: Trong, I Le.]]
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[[Category: Korotkova, N]]
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[[Category: Yang, Y.]]
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[[Category: Marchant, J]]
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[[Category: Matthews, S]]
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[[Category: Moseley, S L]]
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[[Category: Stenkamp, R E]]
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[[Category: Thomas, W E]]
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[[Category: Trong, I Le]]
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[[Category: Yang, Y]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Cell projection]]
[[Category: Cell projection]]

Current revision

Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA)

PDB ID 2ver

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