3k10

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{{STRUCTURE_3k10| PDB=3k10 | SCENE= }}
 
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===Crystal structure of telomere capping protein Stn1 from Saccharomyces cerevisiae===
 
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{{ABSTRACT_PUBMED_19884503}}
 
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==Function==
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==Crystal structure of telomere capping protein Stn1 from Saccharomyces cerevisiae==
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[[http://www.uniprot.org/uniprot/STN1_YEAST STN1_YEAST]] Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.<ref>PMID:9042864</ref><ref>PMID:11230140</ref>
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<StructureSection load='3k10' size='340' side='right'caption='[[3k10]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3k10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K10 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k10 OCA], [https://pdbe.org/3k10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k10 RCSB], [https://www.ebi.ac.uk/pdbsum/3k10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k10 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STN1_YEAST STN1_YEAST] Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.<ref>PMID:9042864</ref> <ref>PMID:11230140</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Telomeres must be capped to preserve chromosomal stability. The conserved Stn1 and Ten1 proteins are required for proper capping of the telomere, although the mechanistic details of how they contribute to telomere maintenance are unclear. Here, we report the crystal structures of the C-terminal domain of the Saccharomyces cerevisiae Stn1 and the Schizosaccharomyces pombe Ten1 proteins. These structures reveal striking similarities to corresponding subunits in the replication protein A complex, further supporting an evolutionary link between telomere maintenance proteins and DNA repair complexes. Our structural and in vivo data of Stn1 identify a new domain that has evolved to support a telomere-specific role in chromosome maintenance. These findings endorse a model of an evolutionarily conserved mechanism of DNA maintenance that has developed as a result of increased chromosomal structural complexity.
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==About this Structure==
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Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.,Gelinas AD, Paschini M, Reyes FE, Heroux A, Batey RT, Lundblad V, Wuttke DS Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19298-303. Epub 2009 Nov 2. PMID:19884503<ref>PMID:19884503</ref>
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[[3k10]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K10 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019884503</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 3k10" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Batey, R T.]]
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[[Category: Batey RT]]
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[[Category: Gelinas, A D.]]
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[[Category: Gelinas AD]]
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[[Category: Reyes, F E.]]
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[[Category: Reyes FE]]
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[[Category: Wuttke, D S.]]
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[[Category: Wuttke DS]]
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[[Category: Chromosomal protein]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Telomere]]
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[[Category: Telomere capping]]
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[[Category: Winged helix turn helix]]
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Current revision

Crystal structure of telomere capping protein Stn1 from Saccharomyces cerevisiae

PDB ID 3k10

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