2xwc
From Proteopedia
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| - | {{STRUCTURE_2xwc| PDB=2xwc | SCENE= }} | ||
| - | ===Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution=== | ||
| - | {{ABSTRACT_PUBMED_22917970}} | ||
| - | == | + | ==Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution== |
| - | [[ | + | <StructureSection load='2xwc' size='340' side='right'caption='[[2xwc]], [[Resolution|resolution]] 1.82Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2xwc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xip 2xip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWC FirstGlance]. <br> |
| - | [[2xwc]] is a 1 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwc OCA], [https://pdbe.org/2xwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwc RCSB], [https://www.ebi.ac.uk/pdbsum/2xwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref> | ||
==See Also== | ==See Also== | ||
*[[P73|P73]] | *[[P73|P73]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Bullock AN]] |
| - | [[Category: | + | [[Category: Canning P]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Ugochukwu | + | [[Category: Ugochukwu E]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Zhang | + | [[Category: Zhang Y]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bullock AN | Canning P | Edwards AM | Krojer T | Muniz JRC | Ugochukwu E | Vollmar M | Weigelt J | Zhang Y | Von Delft F
