4jpz

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'''Unreleased structure'''
 
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The entry 4jpz is ON HOLD
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==Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin==
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<StructureSection load='4jpz' size='340' side='right'caption='[[4jpz]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jpz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JPZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jpz OCA], [https://pdbe.org/4jpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jpz RCSB], [https://www.ebi.ac.uk/pdbsum/4jpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jpz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF13_HUMAN FGF13_HUMAN] Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.<ref>PMID:15282281</ref> May regulate voltage-gated sodium channels transport and function.<ref>PMID:15282281</ref> May also play a role in MAPK signaling.<ref>PMID:15282281</ref>
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Authors: Chung, B.C., Wang, C., Hennessey, J.A., Lee, S.-Y., Pitt, G.S.
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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Description: Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chung BC]]
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[[Category: Lee SY]]
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[[Category: Pitt GS]]
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[[Category: Wang C]]
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[[Category: Wang HG]]
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[[Category: Yan H]]

Current revision

Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin

PDB ID 4jpz

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