1hyk

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{{STRUCTURE_1hyk| PDB=1hyk | SCENE= }}
 
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===AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132))===
 
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{{ABSTRACT_PUBMED_10371151}}
 
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==Disease==
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==AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132))==
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[[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[http://omim.org/entry/601665 601665]]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref>
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<StructureSection load='1hyk' size='340' side='right'caption='[[1hyk]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[1hyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qu8 1qu8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HYK FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN]] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyk OCA], [https://pdbe.org/1hyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hyk RCSB], [https://www.ebi.ac.uk/pdbsum/1hyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hyk ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1hyk]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qu8 1qu8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYK OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:12213871</ref>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:010371151</ref><references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/AGRP_HUMAN AGRP_HUMAN] Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.<ref>PMID:9892020</ref> <ref>PMID:11145747</ref> <ref>PMID:17041250</ref> <ref>PMID:10371151</ref> <ref>PMID:15927146</ref>
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[[Category: Anderson, D J.]]
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== Evolutionary Conservation ==
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[[Category: Bolin, K A.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Kent, S B.H.]]
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Check<jmol>
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[[Category: Millhauser, G L.]]
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<jmolCheckbox>
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[[Category: Thompson, D A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hyk_consurf.spt"</scriptWhenChecked>
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[[Category: Trulson, J A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Wilken, J.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Agouti]]
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</jmolCheckbox>
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[[Category: Agouti-related]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hyk ConSurf].
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[[Category: Agrp]]
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<div style="clear:both"></div>
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[[Category: Cysteine rich]]
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== References ==
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[[Category: Disulfide bond]]
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<references/>
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[[Category: Endogenous antagonist]]
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__TOC__
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[[Category: Ick]]
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</StructureSection>
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[[Category: Inhibitor cystine knot]]
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[[Category: Homo sapiens]]
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[[Category: Melanocortin antagonist]]
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[[Category: Large Structures]]
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[[Category: Signaling protein]]
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[[Category: Anderson DJ]]
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[[Category: Bolin KA]]
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[[Category: Kent SBH]]
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[[Category: Millhauser GL]]
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[[Category: Thompson DA]]
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[[Category: Trulson JA]]
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[[Category: Wilken J]]

Current revision

AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132))

PDB ID 1hyk

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