2ypw

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{{STRUCTURE_2ypw| PDB=2ypw | SCENE= }}
 
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===Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex===
 
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{{ABSTRACT_PUBMED_23511972}}
 
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==About this Structure==
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==Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex==
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[[2ypw]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPW OCA].
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<SX load='2ypw' size='340' side='right' viewer='molstar' caption='[[2ypw]], [[Resolution|resolution]] 12.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ypw]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypw OCA], [https://pdbe.org/2ypw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypw RCSB], [https://www.ebi.ac.uk/pdbsum/2ypw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q46704_ECOLX Q46704_ECOLX]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4. VirB7, 9 and 10 assemble into a 1.07 MegaDalton membrane-spanning core complex (CC), around which all other components assemble. This complex is made of two parts, the O-layer inserted in the outer membrane and the I-layer inserted in the inner membrane. While the structure of the O-layer has been solved by X-ray crystallography, there is no detailed structural information on the I-layer. Using high-resolution cryo-electron microscopy and molecular modelling combined with biochemical approaches, we determined the I-layer structure and located its various components in the electron density. Our results provide new structural insights on the CC, from which the essential features of T4S system mechanisms can be derived.
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Structure of a bacterial type IV secretion core complex at subnanometre resolution.,Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J, Remaut H, Waksman G, Orlova EV EMBO J. 2013 Mar 19. doi: 10.1038/emboj.2013.58. PMID:23511972<ref>PMID:23511972</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ypw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Chandran, V.]]
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[[Category: Large Structures]]
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[[Category: Fronzes, R.]]
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[[Category: Chandran V]]
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[[Category: Laeremans, T.]]
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[[Category: Fronzes R]]
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[[Category: Lian, P W.]]
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[[Category: Laeremans T]]
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[[Category: Orlova, E V.]]
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[[Category: Lian PW]]
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[[Category: Pardon, E.]]
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[[Category: Orlova EV]]
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[[Category: Remaut, H.]]
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[[Category: Pardon E]]
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[[Category: Rivera-Calzada, A.]]
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[[Category: Remaut H]]
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[[Category: Savva, C G.]]
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[[Category: Rivera-Calzada A]]
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[[Category: Steyaert, J.]]
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[[Category: Savva CG]]
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[[Category: Waksman, G.]]
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[[Category: Steyaert J]]
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[[Category: Bacterial secretion]]
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[[Category: Waksman G]]
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[[Category: Membrane protein]]
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[[Category: Type iv secretion]]
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Current revision

Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex

2ypw, resolution 12.40Å

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