3w3m

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{{STRUCTURE_3w3m| PDB=3w3m | SCENE= }}
 
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===Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2===
 
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{{ABSTRACT_PUBMED_23520111}}
 
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==Function==
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==Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2==
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[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
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<StructureSection load='3w3m' size='340' side='right'caption='[[3w3m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W3M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RX8:1-[4-AMINO-2-(ETHOXYMETHYL)-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL]-2-METHYLPROPAN-2-OL'>RX8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w3m OCA], [https://pdbe.org/3w3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w3m RCSB], [https://www.ebi.ac.uk/pdbsum/3w3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w3m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate immune responses. Several synthetic agonists of TLR7-TLR8 display novel therapeutic potential; however, the molecular basis for ligand recognition and activation of signaling by TLR7 or TLR8 is largely unknown. In this study, the crystal structures of unliganded and ligand-induced activated human TLR8 dimers were elucidated. Ligand recognition was mediated by a dimerization interface formed by two protomers. Upon ligand stimulation, the TLR8 dimer was reorganized such that the two C termini were brought into proximity. The loop between leucine-rich repeat 14 (LRR14) and LRR15 was cleaved; however, the N- and C-terminal halves remained associated and contributed to ligand recognition and dimerization. Thus, ligand binding induces reorganization of the TLR8 dimer, which enables downstream signaling processes.
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==About this Structure==
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Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.,Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T Science. 2013 Mar 22;339(6126):1426-9. doi: 10.1126/science.1229159. PMID:23520111<ref>PMID:23520111</ref>
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[[3w3m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W3M OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 3w3m" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ohto, U.]]
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[[Category: Large Structures]]
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[[Category: Shimizu, T.]]
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[[Category: Ohto U]]
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[[Category: Tanji, H.]]
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[[Category: Shimizu T]]
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[[Category: Antivirus and antitumor drug]]
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[[Category: Tanji H]]
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[[Category: Antivirus and antitumor drug binding]]
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[[Category: Glycosylation]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Leucine rich repeat]]
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[[Category: Receptor]]
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[[Category: Resiquimod]]
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[[Category: Rna]]
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[[Category: Rna binding]]
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[[Category: Rna receptor]]
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[[Category: Rna recognition]]
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[[Category: Secreted]]
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[[Category: Ssrna]]
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Current revision

Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2

PDB ID 3w3m

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