3km5

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{{STRUCTURE_3km5| PDB=3km5 | SCENE= }}
 
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===Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)===
 
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{{ABSTRACT_PUBMED_20233299}}
 
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==Function==
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==Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)==
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[[http://www.uniprot.org/uniprot/O52050_PORGI O52050_PORGI]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
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<StructureSection load='3km5' size='340' side='right'caption='[[3km5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3km5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_W83 Porphyromonas gingivalis W83]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KM5 FirstGlance]. <br>
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[[3km5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KM5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3km5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3km5 OCA], [https://pdbe.org/3km5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3km5 RCSB], [https://www.ebi.ac.uk/pdbsum/3km5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3km5 ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020233299</ref><references group="xtra"/><references/>
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</table>
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[[Category: Porphyromonas gingivalis]]
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== Function ==
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[[Category: Collyer, C A.]]
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[https://www.uniprot.org/uniprot/HAGA1_PORGI HAGA1_PORGI] Agglutinates erythrocytes.
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[[Category: Hunter, N.]]
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== Evolutionary Conservation ==
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[[Category: Li, N.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Beta jelly roll barrel]]
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Check<jmol>
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[[Category: Cell invasion]]
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<jmolCheckbox>
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[[Category: Cleaved adhesin family]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3km5_consurf.spt"</scriptWhenChecked>
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[[Category: Hemagglutination domain]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Lys-gingipain]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3km5 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Porphyromonas gingivalis W83]]
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[[Category: Collyer CA]]
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[[Category: Hunter N]]
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[[Category: Li N]]

Current revision

Crystal Structure Analysis of the K2 Cleaved Adhesin Domain of Lys-gingipain (Kgp)

PDB ID 3km5

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