2dyl

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[[Image:2dyl.jpg|left|200px]]<br /><applet load="2dyl" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dyl, resolution 2.45&Aring;" />
 
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'''Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)'''<br />
 
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==About this Structure==
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==Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)==
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2DYL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYL OCA].
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<StructureSection load='2dyl' size='340' side='right'caption='[[2dyl]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Mitogen-activated protein kinase kinase]]
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<table><tr><td colspan='2'>[[2dyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYL FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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[[Category: Kaminishi, T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyl OCA], [https://pdbe.org/2dyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyl RCSB], [https://www.ebi.ac.uk/pdbsum/2dyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyl ProSAT]</span></td></tr>
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[[Category: Kukimoto-Niino, M.]]
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</table>
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[[Category: Matsuzaki, O.]]
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== Function ==
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[https://www.uniprot.org/uniprot/MP2K7_HUMAN MP2K7_HUMAN] Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:9372971</ref> <ref>PMID:9312068</ref> <ref>PMID:9535930</ref> [:]
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[[Category: Shirouzu, M.]]
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== Evolutionary Conservation ==
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[[Category: Takagi, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Terada, T.]]
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Check<jmol>
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[[Category: Uchikubo-Kamo, T.]]
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<jmolCheckbox>
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[[Category: Yokoyama, S.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyl_consurf.spt"</scriptWhenChecked>
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[[Category: activated mutant]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: atp-binding]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: kinase]]
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</jmolCheckbox>
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[[Category: mkk7]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyl ConSurf].
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[[Category: national project on protein structural and functional analyses]]
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<div style="clear:both"></div>
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:09 2008''
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==See Also==
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*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kaminishi T]]
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[[Category: Kukimoto-Niino M]]
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[[Category: Matsuzaki O]]
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[[Category: Shirouzu M]]
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[[Category: Takagi T]]
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[[Category: Terada T]]
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[[Category: Uchikubo-Kamo T]]
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[[Category: Yokoyama S]]

Current revision

Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)

PDB ID 2dyl

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