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2dyl
From Proteopedia
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| - | [[Image:2dyl.jpg|left|200px]]<br /><applet load="2dyl" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dyl, resolution 2.45Å" /> | ||
| - | '''Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)'''<br /> | ||
| - | == | + | ==Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)== |
| - | + | <StructureSection load='2dyl' size='340' side='right'caption='[[2dyl]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2dyl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYL FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyl OCA], [https://pdbe.org/2dyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyl RCSB], [https://www.ebi.ac.uk/pdbsum/2dyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyl ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/MP2K7_HUMAN MP2K7_HUMAN] Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:9372971</ref> <ref>PMID:9312068</ref> <ref>PMID:9535930</ref> [:] | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyl_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyl ConSurf]. |
| - | + | <div style="clear:both"></div> | |
| - | + | ||
| - | [ | + | |
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| + | *[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kaminishi T]] | ||
| + | [[Category: Kukimoto-Niino M]] | ||
| + | [[Category: Matsuzaki O]] | ||
| + | [[Category: Shirouzu M]] | ||
| + | [[Category: Takagi T]] | ||
| + | [[Category: Terada T]] | ||
| + | [[Category: Uchikubo-Kamo T]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)
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