3k5q
From Proteopedia
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| - | {{STRUCTURE_3k5q| PDB=3k5q | SCENE= }} | ||
| - | ===Crystal structure of FBF-2/FBE complex=== | ||
| - | {{ABSTRACT_PUBMED_19901328}} | ||
| - | == | + | ==Crystal structure of FBF-2/FBE complex== |
| - | [[http://www.uniprot.org/uniprot/FBF2_CAEEL FBF2_CAEEL | + | <StructureSection load='3k5q' size='340' side='right'caption='[[3k5q]], [[Resolution|resolution]] 2.20Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3k5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K5Q FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k5q OCA], [https://pdbe.org/3k5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k5q RCSB], [https://www.ebi.ac.uk/pdbsum/3k5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k5q ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/FBF2_CAEEL FBF2_CAEEL] Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform B 3'-UTR.<ref>PMID:9393998</ref> <ref>PMID:15454534</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/3k5q_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k5q ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
| - | [[Category: Hall | + | [[Category: Large Structures]] |
| - | [[Category: Opperman | + | [[Category: Hall TMT]] |
| - | [[Category: Wang | + | [[Category: Opperman L]] |
| - | [[Category: Wickens | + | [[Category: Wang Y]] |
| - | + | [[Category: Wickens M]] | |
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Current revision
Crystal structure of FBF-2/FBE complex
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