2dz7
From Proteopedia
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| - | [[Image:2dz7.jpg|left|200px]]<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2dz7, resolution 1.60Å" /> | ||
| - | '''DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)'''<br /> | ||
| - | == | + | ==DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)== |
| + | <StructureSection load='2dz7' size='340' side='right'caption='[[2dz7]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZ7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dz7 OCA], [https://pdbe.org/2dz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dz7 RCSB], [https://www.ebi.ac.uk/pdbsum/2dz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dz7 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented. | The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented. | ||
| - | + | DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC).,Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599<ref>PMID:17062599</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 2dz7" style="background-color:#fffaf0;"></div> |
| - | [[Category: Kondo | + | == References == |
| - | [[Category: Mitomi | + | <references/> |
| - | [[Category: Sato | + | __TOC__ |
| - | [[Category: Sumani | + | </StructureSection> |
| - | [[Category: Takenaka | + | [[Category: Large Structures]] |
| - | + | [[Category: Kondo J]] | |
| - | + | [[Category: Mitomi K]] | |
| - | + | [[Category: Sato Y]] | |
| - | + | [[Category: Sumani T]] | |
| - | + | [[Category: Takenaka A]] | |
| - | + | ||
| - | + | ||
Current revision
DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)
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Categories: Large Structures | Kondo J | Mitomi K | Sato Y | Sumani T | Takenaka A
