3klo

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{{STRUCTURE_3klo| PDB=3klo | SCENE= }}
 
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===Vibrio cholerae VpsT bound to c-di-GMP===
 
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{{ABSTRACT_PUBMED_20150502}}
 
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==About this Structure==
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==Vibrio cholerae VpsT bound to c-di-GMP==
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[[3klo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLO OCA].
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<StructureSection load='3klo' size='340' side='right'caption='[[3klo]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3klo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor Vibrio cholerae O1 biovar El Tor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KLO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.802&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3klo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3klo OCA], [https://pdbe.org/3klo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3klo RCSB], [https://www.ebi.ac.uk/pdbsum/3klo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3klo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9KKZ8_VIBCH Q9KKZ8_VIBCH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/3klo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3klo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Microorganisms can switch from a planktonic, free-swimming life-style to a sessile, colonial state, called a biofilm, which confers resistance to environmental stress. Conversion between the motile and biofilm life-styles has been attributed to increased levels of the prokaryotic second messenger cyclic di-guanosine monophosphate (c-di-GMP), yet the signaling mechanisms mediating such a global switch are poorly understood. Here we show that the transcriptional regulator VpsT from Vibrio cholerae directly senses c-di-GMP to inversely control extracellular matrix production and motility, which identifies VpsT as a master regulator for biofilm formation. Rather than being regulated by phosphorylation, VpsT undergoes a change in oligomerization on c-di-GMP binding.
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==Reference==
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Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP.,Krasteva PV, Fong JC, Shikuma NJ, Beyhan S, Navarro MV, Yildiz FH, Sondermann H Science. 2010 Feb 12;327(5967):866-8. PMID:20150502<ref>PMID:20150502</ref>
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<ref group="xtra">PMID:020150502</ref><references group="xtra"/><references/>
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[[Category: Vibrio cholerae]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Krasteva, P V.]]
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</div>
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[[Category: Navarro, V A.S.]]
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<div class="pdbe-citations 3klo" style="background-color:#fffaf0;"></div>
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[[Category: Sondermann, H.]]
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== References ==
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[[Category: Dna-binding]]
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<references/>
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[[Category: Hth domain]]
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__TOC__
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[[Category: Rec domain]]
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</StructureSection>
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[[Category: Transcription]]
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[[Category: Large Structures]]
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[[Category: Transcription regulation]]
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[[Category: Vibrio cholerae O1 biovar El Tor]]
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[[Category: Krasteva PV]]
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[[Category: Navarro VAS]]
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[[Category: Sondermann H]]

Current revision

Vibrio cholerae VpsT bound to c-di-GMP

PDB ID 3klo

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