3kpc

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{{STRUCTURE_3kpc| PDB=3kpc | SCENE= }}
 
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===Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine===
 
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{{ABSTRACT_PUBMED_20026078}}
 
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==About this Structure==
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==Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine==
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[[3kpc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPC OCA].
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<StructureSection load='3kpc' size='340' side='right'caption='[[3kpc]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[3kpc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KPC FirstGlance]. <br>
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<ref group="xtra">PMID:020026078</ref><references group="xtra"/><references/>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTA:5-DEOXY-5-METHYLTHIOADENOSINE'>MTA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpc OCA], [https://pdbe.org/3kpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kpc RCSB], [https://www.ebi.ac.uk/pdbsum/3kpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASST_METJA ASST_METJA] Required for O-acetylhomoserine sulfhydrylase (OAHS)-independent homocysteine (Hcy) biosynthesis. Together with MJ0099, catalyzes the condensation of sulfide with aspartate semialdehyde to generate homocysteine. Likely functions through persulfide intermediate.[UniProtKB:Q8TPT4]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kpc ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Arribas, E A.]]
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[[Category: Arribas EA]]
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[[Category: Encinar, J A.]]
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[[Category: Encinar JA]]
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[[Category: Fernandez, J A.]]
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[[Category: Fernandez JA]]
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[[Category: Garcia, I G.]]
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[[Category: Garcia IG]]
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[[Category: Kortazar, D.]]
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[[Category: Kortazar D]]
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[[Category: Lucas, M.]]
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[[Category: Lucas M]]
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[[Category: Martinez-Chantar, M L.]]
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[[Category: Martinez-Chantar ML]]
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[[Category: Martinez-Cruz, L A.]]
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[[Category: Martinez-Cruz LA]]
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[[Category: Mato, J M.]]
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[[Category: Mato JM]]
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[[Category: Oyenarte, I.]]
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[[Category: Oyenarte I]]
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[[Category: Cbs domain]]
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[[Category: Conformational change]]
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[[Category: S-adenosylmethionine]]
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[[Category: Unknown function]]
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Current revision

Crystal Structure of the CBS domain pair of protein MJ0100 in complex with 5 -methylthioadenosine and S-adenosyl-L-methionine

PDB ID 3kpc

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