3kcv

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{{STRUCTURE_3kcv| PDB=3kcv | SCENE= }}
 
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===Structure of formate channel===
 
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{{ABSTRACT_PUBMED_019940917}}
 
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==Function==
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==Structure of formate channel==
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[[http://www.uniprot.org/uniprot/FOCA_ECO57 FOCA_ECO57]] Involved in the bidirectional transport of formate (By similarity).
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<StructureSection load='3kcv' size='340' side='right'caption='[[3kcv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3kcv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KCV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.198&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kcv OCA], [https://pdbe.org/3kcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kcv RCSB], [https://www.ebi.ac.uk/pdbsum/3kcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kcv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOCA_ECO57 FOCA_ECO57] Involved in the bidirectional transport of formate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kcv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kcv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FocA is a representative member of the formate-nitrite transporter family, which transports short-chain acids in bacteria, archaea, fungi, algae and parasites. The structure and transport mechanism of the formate-nitrite transporter family remain unknown. Here we report the crystal structure of Escherichia coli FocA at 2.25 A resolution. FocA forms a symmetric pentamer, with each protomer consisting of six transmembrane segments. Despite a lack of sequence homology, the overall structure of the FocA protomer closely resembles that of aquaporin and strongly argues that FocA is a channel, rather than a transporter. Structural analysis identifies potentially important channel residues, defines the channel path and reveals two constriction sites. Unlike aquaporin, FocA is impermeable to water but allows the passage of formate. A structural and biochemical investigation provides mechanistic insights into the channel activity of FocA.
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==About this Structure==
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Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel.,Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N, Shi Y Nature. 2009 Nov 26;462(7272):467-72. PMID:19940917<ref>PMID:19940917</ref>
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[[3kcv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCV OCA].
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[[Category: Escherichia coli o157:h7]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Huang, Y.]]
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</div>
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[[Category: Shi, Y.]]
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<div class="pdbe-citations 3kcv" style="background-color:#fffaf0;"></div>
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[[Category: Wang, J.]]
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== References ==
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[[Category: Wang, Y.]]
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<references/>
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[[Category: Yan, N.]]
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__TOC__
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[[Category: Cell inner membrane]]
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</StructureSection>
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[[Category: Cell membrane]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Channel]]
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[[Category: Large Structures]]
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[[Category: Formate]]
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[[Category: Huang Y]]
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[[Category: Membrane]]
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[[Category: Shi Y]]
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[[Category: Tcdb id 2 a.44 1.1]]
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[[Category: Wang J]]
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[[Category: Transmembrane]]
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[[Category: Wang Y]]
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[[Category: Transport]]
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[[Category: Yan N]]
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[[Category: Transport protein]]
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[[Category: Transporter]]
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Current revision

Structure of formate channel

PDB ID 3kcv

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