3ks4

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{{STRUCTURE_3ks4| PDB=3ks4 | SCENE= }}
 
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===Crystal structure of Reston ebolavirus VP35 RNA binding domain===
 
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{{ABSTRACT_PUBMED_20018665}}
 
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==Function==
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==Crystal structure of Reston ebolavirus VP35 RNA binding domain==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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<StructureSection load='3ks4' size='340' side='right'caption='[[3ks4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3ks4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KS4 FirstGlance]. <br>
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[[3ks4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS4 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ks4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks4 OCA], [https://pdbe.org/3ks4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ks4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ks4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks4 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:020018665</ref><references group="xtra"/><references/>
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== Function ==
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[[Category: Reston ebolavirus]]
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[https://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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[[Category: Bornholdt, Z A.]]
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== Evolutionary Conservation ==
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[[Category: Kimberlin, C R.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Li, S.]]
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Check<jmol>
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[[Category: Macrae, I J.]]
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<jmolCheckbox>
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[[Category: Saphire, E O.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks4_consurf.spt"</scriptWhenChecked>
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[[Category: Woods, V L.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Ebolavirus]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Host cytoplasm]]
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</jmolCheckbox>
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[[Category: Interferon]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ks4 ConSurf].
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[[Category: Interferon antiviral system evasion]]
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<div style="clear:both"></div>
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[[Category: Protein-rna complex]]
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__TOC__
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[[Category: Reston]]
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</StructureSection>
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[[Category: Rna binding protein]]
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[[Category: Large Structures]]
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[[Category: Rna replication]]
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[[Category: Reston ebolavirus - Reston]]
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[[Category: Rna-binding]]
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[[Category: Bornholdt ZA]]
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[[Category: Rna-binding protein]]
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[[Category: Kimberlin CR]]
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[[Category: Transcription]]
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[[Category: Li S]]
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[[Category: Viral protein]]
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[[Category: Macrae IJ]]
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[[Category: Virion]]
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[[Category: Saphire EO]]
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[[Category: Woods VL]]

Current revision

Crystal structure of Reston ebolavirus VP35 RNA binding domain

PDB ID 3ks4

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OCA

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