3l07

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{{STRUCTURE_3l07| PDB=3l07 | SCENE= }}
 
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===Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative bifunctional protein folD from Francisella tularensis.===
 
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==Function==
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==Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative bifunctional protein folD from Francisella tularensis.==
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[[http://www.uniprot.org/uniprot/FOLD_FRATW FOLD_FRATW]] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).
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<StructureSection load='3l07' size='340' side='right'caption='[[3l07]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3l07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L07 FirstGlance]. <br>
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[[3l07]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L07 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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[[Category: Francisella tularensis]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Anderson, W F.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l07 OCA], [https://pdbe.org/3l07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l07 RCSB], [https://www.ebi.ac.uk/pdbsum/3l07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l07 ProSAT]</span></td></tr>
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[[Category: Hasseman, J.]]
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</table>
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[[Category: Joachimiak, A.]]
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== Function ==
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[[Category: Maltseva, N.]]
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[https://www.uniprot.org/uniprot/FOLD_FRATT FOLD_FRATT] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
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[[Category: Mulligan, R.]]
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== Evolutionary Conservation ==
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[[Category: Osipiuk, J.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Amino-acid biosynthesis]]
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Check<jmol>
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[[Category: Bifunctional protein]]
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<jmolCheckbox>
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[[Category: Center for structural genomics of infectious disease]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l07_consurf.spt"</scriptWhenChecked>
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[[Category: Csgid]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Histidine biosynthesis]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Hydrolase]]
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</jmolCheckbox>
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[[Category: Idp01849]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l07 ConSurf].
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[[Category: Methenyltetrahydrofolate cyclohydrolase]]
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<div style="clear:both"></div>
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[[Category: Methionine biosynthesis]]
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__TOC__
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[[Category: Methylenetetrahydrofolate dehydrogenase]]
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</StructureSection>
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[[Category: Multifunctional enzyme]]
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[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
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[[Category: Nadp]]
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[[Category: Large Structures]]
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[[Category: One-carbon metabolism]]
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[[Category: Anderson WF]]
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[[Category: Oxidoreductase]]
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[[Category: Hasseman J]]
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[[Category: Purine biosynthesis]]
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[[Category: Joachimiak A]]
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[[Category: Structural genomic]]
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[[Category: Maltseva N]]
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[[Category: Mulligan R]]
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[[Category: Osipiuk J]]

Current revision

Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative bifunctional protein folD from Francisella tularensis.

PDB ID 3l07

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