3l6b

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{{STRUCTURE_3l6b| PDB=3l6b | SCENE= }}
 
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===X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor===
 
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{{ABSTRACT_PUBMED_20106978}}
 
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==Function==
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==X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor==
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[[http://www.uniprot.org/uniprot/SRR_HUMAN SRR_HUMAN]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:11054547</ref> <ref>PMID:20106978</ref>
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<StructureSection load='3l6b' size='340' side='right'caption='[[3l6b]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3l6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L6B FirstGlance]. <br>
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[[3l6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l6b OCA], [https://pdbe.org/3l6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l6b RCSB], [https://www.ebi.ac.uk/pdbsum/3l6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l6b ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SRR_HUMAN SRR_HUMAN] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:11054547</ref> <ref>PMID:20106978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/3l6b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l6b ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Serine racemase]]
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[[Category: Large Structures]]
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[[Category: Barker, J.]]
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[[Category: Barker J]]
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[[Category: Cesura, A.]]
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[[Category: Cesura A]]
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[[Category: Ebneth, A.]]
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[[Category: Ebneth A]]
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[[Category: Felicetti, B.]]
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[[Category: Felicetti B]]
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[[Category: Mack, V.]]
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[[Category: Mack V]]
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[[Category: Moraes, I.]]
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[[Category: Moraes I]]
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[[Category: Smith, M A.]]
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[[Category: Smith MA]]
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[[Category: Isomerase]]
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[[Category: Plp]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Serine racemase]]
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Current revision

X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor

PDB ID 3l6b

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