4gab

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{{STRUCTURE_4gab| PDB=4gab | SCENE= }}
 
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===Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat===
 
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{{ABSTRACT_PUBMED_23295227}}
 
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==Function==
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==Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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<StructureSection load='4gab' size='340' side='right'caption='[[4gab]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5971&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FID:(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4-IMIDAZOLIDINE]-2,5-DIONE'>FID</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gab OCA], [https://pdbe.org/4gab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gab RCSB], [https://www.ebi.ac.uk/pdbsum/4gab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gab ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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==About this Structure==
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==See Also==
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[[4gab]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAB OCA].
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Large Structures]]
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[[Category: Figueras, F X.Ruiz.]]
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[[Category: Cousido-Siah A]]
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[[Category: Mitschler, A.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A.]]
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[[Category: Podjarny A]]
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[[Category: Aldo-keto reductase]]
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[[Category: Ruiz Figueras FX]]
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[[Category: Oxidoreductase]]
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[[Category: Tim barrel]]
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Current revision

Human AKR1B10 mutant V301L complexed with NADP+ and fidarestat

PDB ID 4gab

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