4e68

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{{STRUCTURE_4e68| PDB=4e68 | SCENE= }}
 
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===Unphosphorylated STAT3B core protein binding to dsDNA===
 
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{{ABSTRACT_PUBMED_23434585}}
 
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==Function==
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==Unphosphorylated STAT3B core protein binding to dsDNA==
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[[http://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
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<StructureSection load='4e68' size='340' side='right'caption='[[4e68]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E68 FirstGlance]. <br>
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[[4e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.585&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e68 OCA], [https://pdbe.org/4e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e68 RCSB], [https://www.ebi.ac.uk/pdbsum/4e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e68 ProSAT]</span></td></tr>
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==Reference==
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</table>
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<references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Collie, G W.]]
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[[Category: Synthetic construct]]
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[[Category: Parkinson, G N.]]
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[[Category: Collie GW]]
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[[Category: Shah, R.]]
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[[Category: Parkinson GN]]
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[[Category: Activator of transcription]]
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[[Category: Shah R]]
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[[Category: Cytosol]]
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[[Category: Duplex dna]]
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[[Category: Nucleus]]
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[[Category: Protein dna complex]]
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[[Category: Sh2 domain]]
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[[Category: Signal transducer]]
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[[Category: Transcription-dna complex]]
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Current revision

Unphosphorylated STAT3B core protein binding to dsDNA

PDB ID 4e68

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OCA

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