4ed5

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{{STRUCTURE_4ed5| PDB=4ed5 | SCENE= }}
 
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===Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA===
 
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{{ABSTRACT_PUBMED_23519412}}
 
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==Function==
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==Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA==
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[[http://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref>
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<StructureSection load='4ed5' size='340' side='right'caption='[[4ed5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4ed5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ED5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ED5 FirstGlance]. <br>
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[[4ed5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ED5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M2M:1-METHOXY-2-(2-METHOXYETHOXY)ETHANE'>M2M</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ed5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ed5 OCA], [https://pdbe.org/4ed5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ed5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ed5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ed5 ProSAT]</span></td></tr>
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<references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, X.]]
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[[Category: Large Structures]]
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[[Category: Liu, Q.]]
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[[Category: Li X]]
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[[Category: Niu, L.]]
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[[Category: Liu Q]]
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[[Category: Teng, M.]]
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[[Category: Niu L]]
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[[Category: Wang, H.]]
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[[Category: Teng M]]
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[[Category: Zeng, F.]]
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[[Category: Wang H]]
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[[Category: Nucleus]]
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[[Category: Zeng F]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rrm]]
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Current revision

Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA

PDB ID 4ed5

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