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3j2u

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{{STRUCTURE_3j2u| PDB=3j2u | SCENE= }}
 
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===Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule===
 
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{{ABSTRACT_PUBMED_23434508}}
 
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==Function==
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==Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule==
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[[http://www.uniprot.org/uniprot/KI10A_DROME KI10A_DROME]] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".<ref>PMID:14681690</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
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<SX load='3j2u' size='340' side='right' viewer='molstar' caption='[[3j2u]], [[Resolution|resolution]] 10.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3j2u]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. The July 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Microtubules'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_7 10.2210/rcsb_pdb/mom_2014_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J2U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j2u OCA], [https://pdbe.org/3j2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j2u RCSB], [https://www.ebi.ac.uk/pdbsum/3j2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j2u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KI10A_DROME KI10A_DROME] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".<ref>PMID:14681690</ref>
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==About this Structure==
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==See Also==
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[[3j2u]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA].
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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==Reference==
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== References ==
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<references group="xtra"/><references/>
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<references/>
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__TOC__
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</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Gekko coi]]
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[[Category: Drosophila melanogaster]]
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[[Category: Asenjo, A B.]]
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[[Category: Large Structures]]
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[[Category: Chatterjee, C.]]
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[[Category: Microtubules]]
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[[Category: DePaoli, V.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Diaz-Avalos, R.]]
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[[Category: Asenjo AB]]
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[[Category: Rice, W J.]]
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[[Category: Chatterjee C]]
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[[Category: Silvestry, M.]]
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[[Category: DePaoli V]]
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[[Category: Sosa, H.]]
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[[Category: Diaz-Avalos R]]
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[[Category: Tan, D.]]
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[[Category: Rice WJ]]
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[[Category: Depolymerase]]
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[[Category: Silvestry M]]
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[[Category: Depolymerization]]
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[[Category: Sosa H]]
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[[Category: Kinesin]]
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[[Category: Tan D]]
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[[Category: Kinesin-13]]
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[[Category: Kinesin13]]
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[[Category: Kini]]
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[[Category: Microtubule]]
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[[Category: Motor protein]]
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[[Category: Tubulin]]
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Current revision

Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule

3j2u, resolution 10.80Å

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