3jxt

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{{STRUCTURE_3jxt| PDB=3jxt | SCENE= }}
 
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===Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand===
 
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{{ABSTRACT_PUBMED_23480637}}
 
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==Disease==
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==Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand==
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[[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
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<StructureSection load='3jxt' size='340' side='right'caption='[[3jxt]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JXT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DB:(2S)-2-AMINO-4-[5-(DIMETHYLAMINO)-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]BUTANOIC+ACID'>4DB</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxt OCA], [https://pdbe.org/3jxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jxt RCSB], [https://www.ebi.ac.uk/pdbsum/3jxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jxt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
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==Function==
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Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions.,Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637<ref>PMID:23480637</ref>
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[[http://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). [[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3jxt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXT OCA].
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</div>
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<div class="pdbe-citations 3jxt" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Imperiali, B.]]
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[[Category: Imperiali B]]
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[[Category: Olivier, N B.]]
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[[Category: Olivier NB]]
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[[Category: Sainlos, M.]]
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[[Category: Sainlos M]]
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[[Category: 4-dmap]]
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[[Category: 4db]]
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[[Category: Calcium channel]]
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[[Category: Calcium transport]]
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[[Category: Dlg3]]
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[[Category: Fluorogenic probe]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Pdz domain]]
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[[Category: Sap102]]
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[[Category: Signaling protein]]
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[[Category: Solvatochromic flurophore]]
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[[Category: Stargazin]]
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[[Category: Transport]]
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[[Category: Voltage-gated channel]]
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Current revision

Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand

PDB ID 3jxt

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