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3zon

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{{STRUCTURE_3zon| PDB=3zon | SCENE= }}
 
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===Human TYK2 pseudokinase domain bound to a kinase inhibitor===
 
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==Disease==
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==Human TYK2 pseudokinase domain bound to a kinase inhibitor==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
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<StructureSection load='3zon' size='340' side='right'caption='[[3zon]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zon]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZON FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IK1:5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE'>IK1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zon OCA], [https://pdbe.org/3zon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zon RCSB], [https://www.ebi.ac.uk/pdbsum/3zon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zon ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
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== Function ==
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[https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
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*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3zon]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Berridge, G.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Berridge G]]
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[[Category: Chalk, R.]]
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[[Category: Bountra C]]
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[[Category: Daga, N.]]
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[[Category: Chalk R]]
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[[Category: Delft, F von.]]
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[[Category: Daga N]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins JM]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Picaud, S.]]
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[[Category: Picaud S]]
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[[Category: Salah, E.]]
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[[Category: Salah E]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky P]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Jak]]
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[[Category: Von Delft F]]
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[[Category: Transferase]]
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Current revision

Human TYK2 pseudokinase domain bound to a kinase inhibitor

PDB ID 3zon

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