4fx9

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{{STRUCTURE_4fx9| PDB=4fx9 | SCENE= }}
 
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===Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase===
 
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{{ABSTRACT_PUBMED_23530771}}
 
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==Function==
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==Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase==
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[[http://www.uniprot.org/uniprot/CDR_PYRHO CDR_PYRHO]] Acts as a coenzyme A disulfide reductase. Specific for CoA disulfide. Shows a slow NAD(P)H oxidase activity in the presence of high concentrations of substrate-level FAD. This demonstrates that it is not likely to act as an NADH oxidase in vivo.
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<StructureSection load='4fx9' size='340' side='right'caption='[[4fx9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fx9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FX9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fx9 OCA], [https://pdbe.org/4fx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fx9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fx9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCPPR_PYRHO NCPPR_PYRHO] Catalyzes the NAD(P)H-dependent reduction of polysulfide, CoA-polysulfides, and CoA persulfide, as well as the reduction of a range of other small persulfides, including TNB and glutathione persulfides. The likely in vivo substrates are di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficiently reduced (PubMed:23530771). Shows coenzyme A disulfide reductase (CoADR) activity with both NADH and NADPH, with a preference for NADPH (PubMed:15720393). May also play a role in the reduction of elemental sulfur (PubMed:23530771).<ref>PMID:15720393</ref> <ref>PMID:23530771</ref>
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==About this Structure==
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==See Also==
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[[4fx9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii_ot3 Pyrococcus horikoshii ot3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX9 OCA].
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*[[Coenzyme A-Disulfide Reductase|Coenzyme A-Disulfide Reductase]]
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[[Category: CoA-disulfide reductase]]
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== References ==
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[[Category: Pyrococcus horikoshii ot3]]
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<references/>
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[[Category: Herwald, S.]]
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__TOC__
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[[Category: III, E J.Crane.]]
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</StructureSection>
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[[Category: Lopez, K M.]]
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[[Category: Large Structures]]
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[[Category: Sazinsky, M H.]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Disulfide]]
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[[Category: Crane III EJ]]
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[[Category: Oxidoreductase]]
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[[Category: Herwald S]]
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[[Category: Persulfide]]
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[[Category: Lopez KM]]
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[[Category: Polysulfide]]
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[[Category: Sazinsky MH]]
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[[Category: Reductase]]
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Current revision

Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase

PDB ID 4fx9

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