2ebw
From Proteopedia
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| - | [[Image:2ebw.gif|left|200px]]<br /><applet load="2ebw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2ebw" /> | ||
| - | '''Solution structure of the BRCT domain from human DNA repair protein REV1'''<br /> | ||
| - | == | + | ==Solution structure of the BRCT domain from human DNA repair protein REV1== |
| - | + | <StructureSection load='2ebw' size='340' side='right'caption='[[2ebw]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2ebw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBW FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebw OCA], [https://pdbe.org/2ebw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebw RCSB], [https://www.ebi.ac.uk/pdbsum/2ebw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebw ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebw TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebw_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [[ | + | </jmolCheckbox> |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebw ConSurf]. |
| - | [[ | + | <div style="clear:both"></div> |
| - | [ | + | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hayashi F]] | ||
| + | [[Category: Nagashima T]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structure of the BRCT domain from human DNA repair protein REV1
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