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3lxx
From Proteopedia
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| - | {{STRUCTURE_3lxx| PDB=3lxx | SCENE= }} | ||
| - | ===Crystal structure of human GTPase IMAP family member 4=== | ||
| - | == | + | ==Crystal structure of human GTPase IMAP family member 4== |
| - | [[3lxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <StructureSection load='3lxx' size='340' side='right' caption='[[3lxx]], [[Resolution|resolution]] 2.15Å' scene=''> |
| - | [[Category: | + | == Structural highlights == |
| - | [[Category: Andrews, D W | + | <table><tr><td colspan='2'>[[3lxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LXX FirstGlance]. <br> |
| - | [[Category: Arrowsmith, C H | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | [[Category: Bochkarev, A | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: Bountra, C | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxw|3lxw]]</td></tr> |
| - | [[Category: Edwards, A M | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GIMAP4, IAN1, IMAP4, MSTP062 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | [[Category: Mackenzie, F | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxx OCA], [http://pdbe.org/3lxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lxx RCSB], [http://www.ebi.ac.uk/pdbsum/3lxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lxx ProSAT]</span></td></tr> |
| - | [[Category: Nedyalkova, L | + | </table> |
| - | [[Category: Park, H | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/GIMA4_HUMAN GIMA4_HUMAN]] May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium. |
| - | [[Category: Shen, Y | + | == Evolutionary Conservation == |
| - | [[Category: Tempel, W | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[Category: Tong, Y | + | Check<jmol> |
| - | [[Category: Weigelt, J | + | <jmolCheckbox> |
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/3lxx_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lxx ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Andrews, D W]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bochkarev, A]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Mackenzie, F]] | ||
| + | [[Category: Nedyalkova, L]] | ||
| + | [[Category: Park, H]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Shen, Y]] | ||
| + | [[Category: Tempel, W]] | ||
| + | [[Category: Tong, Y]] | ||
| + | [[Category: Weigelt, J]] | ||
| + | [[Category: Coiled coil]] | ||
[[Category: Gtp-binding]] | [[Category: Gtp-binding]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Current revision
Crystal structure of human GTPase IMAP family member 4
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Categories: Human | Andrews, D W | Arrowsmith, C H | Bochkarev, A | Bountra, C | Edwards, A M | Mackenzie, F | Nedyalkova, L | Park, H | Structural genomic | Shen, Y | Tempel, W | Tong, Y | Weigelt, J | Coiled coil | Gtp-binding | Immune system | Nucleotide-binding | Sgc
