3m66
From Proteopedia
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| - | {{STRUCTURE_3m66| PDB=3m66 | SCENE= }} | ||
| - | ===Crystal structure of human Mitochondrial Transcription Termination Factor 3=== | ||
| - | {{ABSTRACT_PUBMED_20430012}} | ||
| - | == | + | ==Crystal structure of human Mitochondrial Transcription Termination Factor 3== |
| - | [[http://www.uniprot.org/uniprot/ | + | <StructureSection load='3m66' size='340' side='right'caption='[[3m66]], [[Resolution|resolution]] 1.60Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3m66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M66 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m66 OCA], [https://pdbe.org/3m66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m66 RCSB], [https://www.ebi.ac.uk/pdbsum/3m66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m66 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | < | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MTEF3_HUMAN MTEF3_HUMAN] Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity).[UniProtKB:Q8R3J4]<ref>PMID:17662942</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m66_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m66 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Gustafsson CM]] |
| - | [[Category: | + | [[Category: Hallberg BM]] |
| - | [[Category: | + | [[Category: Samuelsson T]] |
| - | [[Category: | + | [[Category: Spahr H]] |
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Current revision
Crystal structure of human Mitochondrial Transcription Termination Factor 3
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