2edi
From Proteopedia
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| - | [[Image:2edi.jpg|left|200px]]<br /><applet load="2edi" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2edi" /> | ||
| - | '''Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2'''<br /> | ||
| - | == | + | ==Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2== |
| - | + | <StructureSection load='2edi' size='340' side='right'caption='[[2edi]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | [[ | + | <table><tr><td colspan='2'>[[2edi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDI FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edi OCA], [https://pdbe.org/2edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edi RCSB], [https://www.ebi.ac.uk/pdbsum/2edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edi ProSAT], [https://www.topsan.org/Proteins/RSGI/2edi TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/UBE2F_HUMAN UBE2F_HUMAN] Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/2edi_consurf.spt"</scriptWhenChecked> | |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [[ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2edi ConSurf]. | |
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Endo H]] | ||
| + | [[Category: Hayashi F]] | ||
| + | [[Category: Izumi K]] | ||
| + | [[Category: Yokoyama S]] | ||
| + | [[Category: Yoshida M]] | ||
Current revision
Solution structure of the UQ_con domain from human NEDD8-conjugating enzyme NCE2
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Categories: Homo sapiens | Large Structures | Endo H | Hayashi F | Izumi K | Yokoyama S | Yoshida M
