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3lyn

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{{STRUCTURE_3lyn| PDB=3lyn | SCENE= }}
 
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===STRUCTURE OF GREEN ABALONE LYSIN DIMER===
 
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{{ABSTRACT_PUBMED_10698629}}
 
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==Function==
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==STRUCTURE OF GREEN ABALONE LYSIN DIMER==
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[[http://www.uniprot.org/uniprot/ELYS_HALFU ELYS_HALFU]] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.
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<StructureSection load='3lyn' size='340' side='right'caption='[[3lyn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliotis_fulgens Haliotis fulgens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LYN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lyn OCA], [https://pdbe.org/3lyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lyn RCSB], [https://www.ebi.ac.uk/pdbsum/3lyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lyn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELYS_HALFU ELYS_HALFU] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ly/3lyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lyn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Abalone sperm lysin is a 16 kDa acrosomal protein used by sperm to create a hole in the egg vitelline envelope. Lysins from seven California abalone exhibit species-specificity in binding to their egg receptor, and range in sequence identity from 63 % to 90 %. The crystal structure of the sperm lysin dimer from Haliotis fulgens (green abalone) has been determined to 1.71 A by multiple isomorphous replacement. Comparisons with the structure of the lysin dimer from Haliotis rufescens (red abalone) reveal a similar overall fold and conservation of features contributing to lysin's amphipathic character. The two structures do, however, exhibit differences in surface residues and electrostatics. A large clustering of non-conserved surface residues around the waist and clefts of the dimer, and differences in charged residues around these regions, indicate areas of the molecule which may be involved in species-specific egg recognition.
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==About this Structure==
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The high resolution crystal structure of green abalone sperm lysin: implications for species-specific binding of the egg receptor.,Kresge N, Vacquier VD, Stout CD J Mol Biol. 2000 Mar 10;296(5):1225-34. PMID:10698629<ref>PMID:10698629</ref>
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[[3lyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haliotis_fulgens Haliotis fulgens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LYN OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:010698629</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 3lyn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Lysin 3D structures|Lysin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Haliotis fulgens]]
[[Category: Haliotis fulgens]]
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[[Category: Kresge, N.]]
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[[Category: Large Structures]]
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[[Category: Stout, C D.]]
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[[Category: Kresge N]]
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[[Category: Vacquier, V D.]]
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[[Category: Stout CD]]
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[[Category: Abalone lysin]]
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[[Category: Vacquier VD]]
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[[Category: Cell adhesion]]
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[[Category: Fertilization protein]]
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[[Category: Gamete recognition protein]]
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Current revision

STRUCTURE OF GREEN ABALONE LYSIN DIMER

PDB ID 3lyn

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