3m9q

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{{STRUCTURE_3m9q| PDB=3m9q | SCENE= }}
 
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===Drosophila MSL3 chromodomain===
 
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{{ABSTRACT_PUBMED_20657587}}
 
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==Function==
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==Drosophila MSL3 chromodomain==
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[[http://www.uniprot.org/uniprot/MSL3_DROME MSL3_DROME]] The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding.<ref>PMID:7768187</ref>
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<StructureSection load='3m9q' size='340' side='right'caption='[[3m9q]], [[Resolution|resolution]] 1.29&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m9q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M9Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m9q OCA], [https://pdbe.org/3m9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m9q RCSB], [https://www.ebi.ac.uk/pdbsum/3m9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m9q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSL3_DROME MSL3_DROME] The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding.<ref>PMID:7768187</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/3m9q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m9q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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MSL3 resides in the MSL (male-specific lethal) complex, which upregulates transcription by spreading the histone H4 Lys16 (H4K16) acetyl mark. We discovered a DNA-dependent interaction of MSL3 chromodomain with the H4K20 monomethyl mark. The structure of a ternary complex shows that the DNA minor groove accommodates the histone H4 tail, and monomethyllysine inserts in a four-residue aromatic cage in MSL3. H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications.
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==About this Structure==
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Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.,Kim D, Blus BJ, Chandra V, Huang P, Rastinejad F, Khorasanizadeh S Nat Struct Mol Biol. 2010 Aug;17(8):1027-9. Epub 2010 Jul 25. PMID:20657587<ref>PMID:20657587</ref>
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[[3m9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9Q OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020657587</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 3m9q" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Huang, P.]]
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[[Category: Large Structures]]
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[[Category: Khorasanizadeh, S.]]
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[[Category: Huang P]]
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[[Category: Kim, D.]]
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[[Category: Khorasanizadeh S]]
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[[Category: Rastinejad, F.]]
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[[Category: Kim D]]
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[[Category: Aromatic cage]]
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[[Category: Rastinejad F]]
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[[Category: Chromodomain]]
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[[Category: Dna binding protein]]
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[[Category: Methyllysine recognition]]
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[[Category: Msl complex]]
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[[Category: Msl3]]
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[[Category: Transcription upregulation]]
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Current revision

Drosophila MSL3 chromodomain

PDB ID 3m9q

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