3mcf

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{{STRUCTURE_3mcf| PDB=3mcf | SCENE= }}
 
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===Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha===
 
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==Function==
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==Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha==
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[[http://www.uniprot.org/uniprot/NUD10_HUMAN NUD10_HUMAN]] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
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<StructureSection load='3mcf' size='340' side='right'caption='[[3mcf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3mcf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MCF FirstGlance]. <br>
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[[3mcf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCF OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mcf OCA], [https://pdbe.org/3mcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mcf RCSB], [https://www.ebi.ac.uk/pdbsum/3mcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mcf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUD10_HUMAN NUD10_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/3mcf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mcf ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Berg, S van der.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berglund, H.]]
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[[Category: Berglund H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Collins, R.]]
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[[Category: Collins R]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Flodin, S.]]
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[[Category: Flodin S]]
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[[Category: Flores, A.]]
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[[Category: Flores A]]
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[[Category: Graslund, S.]]
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[[Category: Graslund S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hammarstrom M]]
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[[Category: Johansson, I.]]
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[[Category: Johansson I]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg T]]
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[[Category: Kol, S.]]
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[[Category: Kol S]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova T]]
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[[Category: Moche, M.]]
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[[Category: Moche M]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman T]]
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[[Category: Persson, C.]]
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[[Category: Persson C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schuler H]]
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[[Category: Schuler, H.]]
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[[Category: Schutz P]]
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[[Category: Schutz, P.]]
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[[Category: Siponen MI]]
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[[Category: Siponen, M I.]]
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[[Category: Thorsell AG]]
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[[Category: Thorsell, A G.]]
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[[Category: Tresaugues L]]
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[[Category: Tresaugues, L.]]
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[[Category: Wahlberg E]]
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[[Category: Wahlberg, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: Wisniewska M]]
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[[Category: Wisniewska, M.]]
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[[Category: Van der Berg S]]
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[[Category: Aps2]]
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[[Category: Diphosphoinositol pentakisphosphate]]
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[[Category: Dipp3a]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Nudix]]
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[[Category: Nudt10]]
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[[Category: Sgc]]
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[[Category: Sgc stockholm]]
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[[Category: Signal transduction]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha

PDB ID 3mcf

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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