3lrp

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{{STRUCTURE_3lrp| PDB=3lrp | SCENE= }}
 
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===Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1===
 
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{{ABSTRACT_PUBMED_021045287}}
 
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==Function==
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==Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1==
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[[http://www.uniprot.org/uniprot/ARF1_PLAFA ARF1_PLAFA]] GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).
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<StructureSection load='3lrp' size='340' side='right'caption='[[3lrp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrp OCA], [https://pdbe.org/3lrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrp RCSB], [https://www.ebi.ac.uk/pdbsum/3lrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARF1_PLAF7 ARF1_PLAF7] Small GTPase involved in protein trafficking between different compartments (PubMed:21045287). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Regulates the transport of N-acylated AK2 to the parasitophorous vacuole membrane (PubMed:33604307). May be involved in the activation of lipid kinase PIP5K (PubMed:19171150).[UniProtKB:P84077]<ref>PMID:19171150</ref> <ref>PMID:21045287</ref> <ref>PMID:33604307</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 A resolution and is compared with the structures of mammalian ARF1s.
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==About this Structure==
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Structure of Plasmodium falciparum ADP-ribosylation factor 1.,Cook WJ, Smith CD, Senkovich O, Holder AA, Chattopadhyay D Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1426-31. Epub 2010 Oct 27. PMID:21045287<ref>PMID:21045287</ref>
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[[3lrp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRP OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3lrp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Chattopadhyay, D.]]
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[[Category: Chattopadhyay D]]
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[[Category: Cook, W J.]]
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[[Category: Cook WJ]]
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[[Category: Adp-ribosylation factor]]
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[[Category: Er-golgi transport]]
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[[Category: Golgi apparatus]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein trafficking]]
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[[Category: Protein transport]]
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[[Category: Signaling protein]]
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[[Category: Transport]]
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Current revision

Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1

PDB ID 3lrp

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