3m4w

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{{STRUCTURE_3m4w| PDB=3m4w | SCENE= }}
 
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===Structural basis for the negative regulation of bacterial stress response by RseB===
 
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{{ABSTRACT_PUBMED_20512978}}
 
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==Function==
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==Structural basis for the negative regulation of bacterial stress response by RseB==
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[[http://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI]] Seems to modulate the activity of RpoE (sigma-E). [[http://www.uniprot.org/uniprot/RSEA_ECOLI RSEA_ECOLI]] Negative regulator of RpoE.
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<StructureSection load='3m4w' size='340' side='right'caption='[[3m4w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m4w]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4w OCA], [https://pdbe.org/3m4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4w RCSB], [https://www.ebi.ac.uk/pdbsum/3m4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI] Seems to modulate the activity of RpoE (sigma-E).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m4w ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sigmaE-dependent stress response in bacterial cells is initiated by the DegS- and RseP-regulated intramembrane proteolysis of a membrane-spanning antisigma factor, RseA. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. In the crystal structure of the periplasmic domain of RseA bound to RseB, the DegS cleavage site of RseA is unstructured, however, its P1 residue is buried in the hydrophobic pocket of RseB, which suggests that RseB binding blocks the access of DegS to the cleavage site.
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==About this Structure==
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Structural basis for the negative regulation of bacterial stress response by RseB.,Kim DY, Kwon E, Choi J, Hwang HY, Kim KK Protein Sci. 2010 Jun;19(6):1258-63. PMID:20512978<ref>PMID:20512978</ref>
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[[3m4w]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020512978</ref><references group="xtra"/><references/>
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</div>
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[[Category: Escherichia coli]]
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<div class="pdbe-citations 3m4w" style="background-color:#fffaf0;"></div>
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[[Category: Choi, J K.]]
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== References ==
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[[Category: Hwang, H Y.]]
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<references/>
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[[Category: Kim, D Y.]]
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__TOC__
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[[Category: Kim, K K.]]
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</StructureSection>
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[[Category: Kwon, E.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Cell membrane]]
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[[Category: Large Structures]]
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[[Category: Rsea]]
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[[Category: Choi JK]]
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[[Category: Rseb]]
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[[Category: Hwang H-Y]]
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[[Category: Rsep]]
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[[Category: Kim DY]]
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[[Category: Sigma factor]]
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[[Category: Kim KK]]
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[[Category: Signaling protein-signaling protein complex]]
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[[Category: Kwon E]]
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[[Category: Stress response]]
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[[Category: Transmembrane]]
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Current revision

Structural basis for the negative regulation of bacterial stress response by RseB

PDB ID 3m4w

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