2ega

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:50, 29 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2ega.jpg|left|200px]]<br /><applet load="2ega" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2ega" />
 
-
'''Solution structure of the first SH3 domain from human KIAA0418 protein'''<br />
 
-
==About this Structure==
+
==Solution structure of the first SH3 domain from human KIAA0418 protein==
-
2EGA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA].
+
<StructureSection load='2ega' size='340' side='right'caption='[[2ega]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGA FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ega OCA], [https://pdbe.org/2ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ega RCSB], [https://www.ebi.ac.uk/pdbsum/2ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ega ProSAT], [https://www.topsan.org/Proteins/RSGI/2ega TOPSAN]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eg/2ega_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ega ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hayashi, F.]]
+
[[Category: Hayashi F]]
-
[[Category: Inoue, K.]]
+
[[Category: Inoue K]]
-
[[Category: Kurosaki, C.]]
+
[[Category: Kurosaki C]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yoshida M]]
-
[[Category: Yoshida, M.]]
+
-
[[Category: kiaa0418 protein]]
+
-
[[Category: national project on protein structural and functional analyses]]
+
-
[[Category: nppsfa]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: sh3 domain]]
+
-
[[Category: sh3 multiple domains 1]]
+
-
[[Category: sh3md1]]
+
-
[[Category: signaling protein]]
+
-
[[Category: structural genomics]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:09:42 2008''
+

Current revision

Solution structure of the first SH3 domain from human KIAA0418 protein

PDB ID 2ega

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ega"
Personal tools