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3lwt

From Proteopedia

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{{STRUCTURE_3lwt| PDB=3lwt | SCENE= }}
 
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===Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function===
 
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{{ABSTRACT_PUBMED_20389282}}
 
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==Function==
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==Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function==
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[[http://www.uniprot.org/uniprot/SAC1_YEAST SAC1_YEAST]] Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.<ref>PMID:10625610</ref> <ref>PMID:11514624</ref>
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<StructureSection load='3lwt' size='340' side='right'caption='[[3lwt]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.956&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwt OCA], [https://pdbe.org/3lwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwt RCSB], [https://www.ebi.ac.uk/pdbsum/3lwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAC1_YEAST SAC1_YEAST] Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.<ref>PMID:10625610</ref> <ref>PMID:11514624</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwt ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3lwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWT OCA].
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:020389282</ref><references group="xtra"/><references/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Emr, S D.]]
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[[Category: Emr SD]]
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[[Category: Hu, F.]]
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[[Category: Hu F]]
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[[Category: Manford, A.]]
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[[Category: Manford A]]
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[[Category: Mao, Y.]]
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[[Category: Mao Y]]
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[[Category: Saxena, A K.]]
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[[Category: Saxena AK]]
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[[Category: Stefan, C.]]
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[[Category: Stefan C]]
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[[Category: Xia, T.]]
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[[Category: Xia T]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Hydrolase]]
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[[Category: Lipid metabolism]]
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[[Category: Membrane]]
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[[Category: Phosphoinositide phosphatase]]
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[[Category: Sac1]]
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[[Category: Sac3/fig4]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function

PDB ID 3lwt

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