3m5l

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{{STRUCTURE_3m5l| PDB=3m5l | SCENE= }}
 
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===Crystal structure of HCV NS3/4A protease in complex with ITMN-191===
 
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{{ABSTRACT_PUBMED_21084633}}
 
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==About this Structure==
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==Crystal structure of HCV NS3/4A protease in complex with ITMN-191==
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[[3m5l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M5L OCA].
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<StructureSection load='3m5l' size='340' side='right'caption='[[3m5l]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M5L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSV:(2R,6S,12Z,13AS,14AR,16AS)-6-[(TERT-BUTOXYCARBONYL)AMINO]-14A-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-2-YL+4-FLUORO-2H-ISOINDOLE-2-CARBOXYLATE'>TSV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m5l OCA], [https://pdbe.org/3m5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m5l RCSB], [https://www.ebi.ac.uk/pdbsum/3m5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m5l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:021084633</ref><references group="xtra"/><references/>
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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[[Category: Hepacivirin]]
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__TOC__
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[[Category: Hepatitis c virus subtype 1a]]
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</StructureSection>
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[[Category: Romano, K P.]]
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[[Category: Hepatitis C virus genotype 1a]]
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[[Category: Schiffer, C A.]]
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[[Category: Large Structures]]
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[[Category: Chimera protein]]
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[[Category: Romano KP]]
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[[Category: Drug resistance]]
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[[Category: Schiffer CA]]
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[[Category: Fusion protein]]
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[[Category: Hcv]]
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[[Category: Hepatitis c virus]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Ns3]]
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[[Category: Protease]]
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[[Category: Serine protease]]
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Current revision

Crystal structure of HCV NS3/4A protease in complex with ITMN-191

PDB ID 3m5l

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