4fgh
From Proteopedia
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| - | {{STRUCTURE_4fgh| PDB=4fgh | SCENE= }} | ||
| - | ===S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor=== | ||
| - | {{ABSTRACT_PUBMED_22930550}} | ||
| - | == | + | ==S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor== |
| - | [[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU | + | <StructureSection load='4fgh' size='340' side='right'caption='[[4fgh]], [[Resolution|resolution]] 2.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FGH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0U6:(2E)-3-{5-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)METHYL]-2,3-DIMETHOXYPHENYL}-1-[(1S)-1-(2-METHYLPROP-1-EN-1-YL)PHTHALAZIN-2(1H)-YL]PROP-2-EN-1-ONE'>0U6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fgh OCA], [https://pdbe.org/4fgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fgh RCSB], [https://www.ebi.ac.uk/pdbsum/4fgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fgh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Barrow | + | [[Category: Barrow WW]] |
| - | [[Category: Bourne | + | [[Category: Bourne CR]] |
| - | + | ||
Current revision
S. aureus dihydrofolate reductase co-crystallized with ethyl-DAP isobutenyl-dihydrophthalazine inhibitor
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