4ja8
From Proteopedia
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| - | {{STRUCTURE_4ja8| PDB=4ja8 | SCENE= }} | ||
| - | ===Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor=== | ||
| - | {{ABSTRACT_PUBMED_23558173}} | ||
| - | == | + | ==Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor== |
| - | [[4ja8]] is a 2 chain structure with sequence from [ | + | <StructureSection load='4ja8' size='340' side='right'caption='[[4ja8]], [[Resolution|resolution]] 1.55Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ja8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1K9:1-[5-(CYCLOPROPYLSULFAMOYL)-2-THIOPHEN-3-YL-PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA'>1K9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja8 OCA], [https://pdbe.org/4ja8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] D-2-hydroxyglutaric aciduria. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2) [MIM:[https://omim.org/entry/613657 613657]. D2HGA2 is a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.<ref>PMID:20847235</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IDHP_HUMAN IDHP_HUMAN] Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chen | + | [[Category: Large Structures]] |
| - | [[Category: DeLaBarre | + | [[Category: Chen L]] |
| - | [[Category: Jiang | + | [[Category: DeLaBarre B]] |
| - | [[Category: Qian | + | [[Category: Jiang F]] |
| - | [[Category: Travins | + | [[Category: Qian K]] |
| - | [[Category: Wei | + | [[Category: Travins J]] |
| - | [[Category: Wu | + | [[Category: Wei W]] |
| - | + | [[Category: Wu M]] | |
| - | + | ||
| - | + | ||
Current revision
Complex of Mitochondrial Isocitrate Dehydrogenase R140Q Mutant with AGI-6780 Inhibitor
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Categories: Homo sapiens | Large Structures | Chen L | DeLaBarre B | Jiang F | Qian K | Travins J | Wei W | Wu M
