4fwu

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{{STRUCTURE_4fwu| PDB=4fwu | SCENE= }}
 
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===Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4===
 
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{{ABSTRACT_PUBMED_23545638}}
 
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==About this Structure==
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==Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4==
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[[4fwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWU OCA].
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<StructureSection load='4fwu' size='340' side='right'caption='[[4fwu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FWU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwu OCA], [https://pdbe.org/4fwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fwu RCSB], [https://www.ebi.ac.uk/pdbsum/4fwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fwu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QPCT1_DROME QPCT1_DROME] Acts as a glutaminyl-peptide cyclotransferase (PubMed:17722885, PubMed:22897232). Responsible for the biosynthesis of pyroglutamyl peptides (By similarity). Might be more efficient in the conversion of tri and tetrapeptides in vitro (PubMed:17722885). Might have a relative preference for substrates containing hydrophobic amino acids in vitro (PubMed:17722885).[UniProtKB:Q16769]<ref>PMID:17722885</ref> <ref>PMID:22897232</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of ligand-free glutaminyl cyclase (QC) from Drosophila melanogaster (DmQC) has been determined in a novel crystal form. The protein crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 A. The crystal diffracted to a resolution of 2 A at the home source. The structure was solved by molecular replacement and was refined to an R factor of 0.169. DmQC exhibits a typical alpha/beta-hydrolase fold. The electron density of three monosaccharides could be localized. The accessibility of the active site will facilitate structural studies of novel inhibitor-binding modes.
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Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.,Kolenko P, Koch B, Rahfeld JU, Schilling S, Demuth HU, Stubbs MT Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):358-61., doi: 10.1107/S1744309113005575. Epub 2013 Mar 28. PMID:23545638<ref>PMID:23545638</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4fwu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutaminyl cyclase|Glutaminyl cyclase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Koch, B.]]
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[[Category: Large Structures]]
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[[Category: Kolenko, P.]]
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[[Category: Koch B]]
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[[Category: Stubbs, M T.]]
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[[Category: Kolenko P]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Stubbs MT]]
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[[Category: Alzheimer`s disease]]
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[[Category: Glycosylation]]
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[[Category: Hydrolase]]
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[[Category: Pglu formation]]
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[[Category: Pglu-amyloid]]
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[[Category: Pyroglutamate]]
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Current revision

Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4

PDB ID 4fwu

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