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4bea
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative== | |
| + | <StructureSection load='4bea' size='340' side='right'caption='[[4bea]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4bea]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BEA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bea OCA], [https://pdbe.org/4bea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bea RCSB], [https://www.ebi.ac.uk/pdbsum/4bea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bea ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Brown CJ]] | ||
| + | [[Category: Lama D]] | ||
| + | [[Category: Lane DP]] | ||
| + | [[Category: Quah ST]] | ||
| + | [[Category: Verma CS]] | ||
Current revision
Crystal Structure of eIF4E in Complex with a Stapled Peptide Derivative
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